Glutathione-complexed iron-sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability.

Glutathione-complexed iron-sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability.
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DOI:
10.1039/c3cc43620a
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发表时间:
2013-07-18
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Cowan JA
Cowan JA
中科院分区:
其他
文献类型:
--
作者:
Qi W;Li J;Chain CY;Pasquevich GA;Pasquevich AF;Cowan JA

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Assembly and stabilization of a glutathione-complexed [2Fe-2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate species, and in turn the core is stabilized toward hydrolytic degradation. Studies of glutathione derivatives, in combination with mass spectrometric and Mössbauer investigations provide insight on reaction intermediates during formation of [2Fe-2S](GS)42-.
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