Non-synaptic transmission at autonomic neuroeffector junctions
Non-synaptic transmission at autonomic neuroeffector junctions
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DOI：
10.1016/j.neuint.2007.03.007
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发表时间：
2008-01-01
影响因子：
4.2
通讯作者：
Bumstock, Geoffrey
中科院分区：
文献类型：
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作者：
Bumstock, Geoffrey
非突触传递是自主神经效应器连接的特征。描述了自主神经肌肉接头的结构。其基本特征是：自主神经纤维的终末部分是曲张的和可移动的，递质从距离效应器细胞不同的距离被释放；虽然效应器细胞上没有结构性的连接后专门化，但神经递质的受体积累在紧密连接的细胞膜上；肌肉效应器是成束的而不是单个的平滑肌细胞，通过缝隙连接连接，允许细胞之间的电紧张性传播活动。多种递质被自主神经利用，尽管神经递质释放的神经调节在连接前和连接后也会发生，但共同传递经常涉及协同递质的协同作用。提示免疫细胞、上皮细胞和内皮细胞的自主神经控制也涉及非突触传递。(C)2007爱思唯尔有限公司。保留所有权利。
Non-synaptic transmission is characteristic of autonomic neuroeffector junctions. The structure of the autonomic neuromuscular junction is described. The essential features are that: the terminal portions of autonomic nerve fibers are varicose and mobile, transmitters being released 'en passage' from varying distances from the effector cells; while there is no structural post-junctional specialization on effector cells, receptors for neurotransmitters accumulate on cell membranes at close junctions; muscle effectors are bundles rather than single smooth muscle cells, that are connected by gap junctions which allow electrotonic spread of activity between cells. A multiplicity of transmitters are utilized by autonomic nerves, and cotransmission occurs often involving synergistic actions of the cotransmitters, although pre- and post-junctional neuromodulation of neurotransmitter release also take place. It is suggested that autonomic neural control of immune, epithelial and endothelial cells also involves non-synaptic transmission. (C) 2007 Elsevier Ltd. All rights reserved.