Optical Resolution of Aromatic Alcohols Using Silica Nanoparticles Grafted with Helicene
Optical Resolution of Aromatic Alcohols Using Silica Nanoparticles Grafted with Helicene
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DOI：
10.1021/ol301206r
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发表时间：
2012-06-15
期刊：
影响因子：
5.2
通讯作者：
Yamaguchi, Masahiko
中科院分区：
文献类型：
--
作者：
Ichinose, Wataru;Miyagawa, Masamichi;Yamaguchi, Masahiko
合成了直径为70 nm的（P）-1，12-二甲基-8-甲氧羰基苯并[c]菲-5-甲酰胺接枝的光学活性二氧化硅纳米粒子，并考察了其在芳香醇动力学拆分中的应用。（S）-2，2-二甲基-1-苯基-1-丙醇通过与（P）-纳米颗粒形成的聚集体的优先沉淀获得高达61%ee。
Optically active silica nanoparticles, with a 70-nm diameter, grafted with (P)-1,12-dimethyl-8-methoxycarbonylbenzo[c]phenanthrene-5-carboxyamide were synthesized, and their use in the kinetic resolution of aromatic alcohols was examined. Up to 61% ee for (S)-2,2-dimethyl-1-phenyl-1-propanol was obtained by a preferential precipitation of aggregates formed with (P)-nanoparticles.