Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex
Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex
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DOI：
10.1038/nn1866
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发表时间：
2007-04-01
影响因子：
25
通讯作者：
Isaac, John T. R.
中科院分区：
文献类型：
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作者：
Daw, Michael I.;Ashby, Michael C.;Isaac, John T. R.
前馈抑制性GABA能传递对成熟的皮层回路功能至关重要;然而，在新生儿中，GABA是去极化的，并且被认为具有不同的作用。在这里，我们表明，GABA（A）受体介导的电导是去极化的兴奋性（星状）细胞在新生儿（出生后[P]3-5天）的第四层桶皮质，但GABA能传输在这个年龄是不参与丘脑皮层输入前馈回路，并没有可检测的电路功能。然而，在P6-7发生募集，这是由于丘脑驱动快速尖峰中间神经元、快速尖峰中间神经元-星状细胞连接和GABA（A）受体介导的反应的超极化的协调增加。因此，GABA能回路在新生儿中不受丘脑皮质输入的影响，但在出生后第一周结束时，正准备进行前馈抑制的显著协调发展，这对发育中这个关键时期的回路功能有深远的影响。
Feedforward inhibitory GABAergic transmission is critical for mature cortical circuit function; in the neonate, however, GABA is depolarizing and believed to have a different role. Here we show that the GABA(A) receptor-mediated conductance is depolarizing in excitatory (stellate) cells in neonatal (postnatal day [P]3-5) layer IV barrel cortex, but GABAergic transmission at this age is not engaged by thalamocortical input in the feedforward circuit and has no detectable circuit function. However, recruitment occurs at P6-7 as a result of coordinated increases in thalamic drive to fast-spiking interneurons, fast-spiking interneuron-stellate cell connectivity and hyperpolarization of the GABA(A) receptor-mediated response. Thus, GABAergic circuits are not engaged by thalamocortical input in the neonate, but are poised for a remarkably coordinated development of feedforward inhibition at the end of the first postnatal week, which has profound effects on circuit function at this critical time in development.