Lead- and drug-like compounds: the rule-of-five revolution.
Lead- and drug-like compounds: the rule-of-five revolution.
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DOI：
10.1016/j.ddtec.2004.11.007
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Lipinski, Christopher A
中科院分区：
文献类型：
--
作者：
Lipinski, Christopher A
Citations in CAS SciFinder to the rule-of-five (RO5) publication will exceed 1000 by year-end 2004. Trends in the RO5 literature explosion that can be discerned are the further definitions of drug-like. This topic is explored in terms of drug-like physicochemical features, drug-like structural features, a comparison of drug-like and non-drug-like in drug discovery and a discussion of how drug-like features relate to clinical success. Physicochemical features of CNS drugs and features related to CNS blood-brain transporter affinity are briefly reviewed. Recent literature on features of non-oral drugs is reviewed and how features of lead-like compounds differ from those of drug-like compounds is discussed. Most recently, partly driven by NIH roadmap initiatives, considerations have arisen as to what tool-like means in the search for chemical tools to probe biology space. All these topics frame the scope of this short review/perspective.:
