Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
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DOI：
10.1371/journal.pone.0042943
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lappas M
中科院分区：
文献类型：
--
作者：
Barker G;Lim R;Georgiou HM;Lappas M
本研究的目的是确定（i）母体肥胖和妊娠期糖尿病（GDM）对（i）脐带和母体血浆中网膜素-1的循环水平，和（ii）基因表达和从人胎盘和脂肪组织释放网膜素-1的影响。还确定了怀孕对循环omentin-1水平的影响。在足月择期剖腹产时，测量肥胖和非肥胖正常葡萄糖耐受妇女（NGT; n = 44）和GDM妇女（n =39）的母体和脐带血浆中网膜素-1水平。 胎盘和脂肪组织的表达和网膜素-1的释放进行了测量，从22 NGT和22 GDM妇女收集在足月择期剖腹产的时间。还测量了13名NGT妇女在妊娠11周和28周以及产后7周的母体血浆中的网膜素-1水平。母亲肥胖与母亲血浆中网膜素-1水平显著降低相关;然而，母亲肥胖对脐带网膜素水平没有影响。从已有肥胖症的妇女中获得的胎盘和脂肪组织中网膜素-1基因表达较低。除此之外，肥胖孕妇的脂肪组织释放网膜蛋白-1显著较低。与非肥胖NGT女性相比，非肥胖GDM中的网膜素-1水平显著降低。然而，肥胖NGT和肥胖GDM女性之间的omentin-1水平没有差异。妊娠期糖尿病对脐带网膜素水平、胎盘和脂肪组织网膜素-1表达无影响。孕妇网膜素-1水平与胎儿出生体重和体重指数呈负相关。本研究中提供的数据表明，预先存在的母体肥胖与胎盘、脂肪组织和母体血浆中网膜素-1表达降低相关。妊娠期omentin-1的改变可能会影响后代日后代谢紊乱的发展。
The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined. Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum. Maternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index. The data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.
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影响因子：
4.5
作者：
Moreno-Navarrete JM;Catalán V;Ortega F;Gómez-Ambrosi J;Ricart W;Frühbeck G;Fernández-Real JM
通讯作者：
Fernández-Real JM
影响因子：
3.8
作者：
Georgiou, Harry M.;Lappas, Martha;Rice, Gregory E.
通讯作者：
Rice, Gregory E.
影响因子：
3.6
作者：
Lappas, Martha;Mitton, Amberlee;Permezel, Michael
通讯作者：
Permezel, Michael
影响因子：
3.6
作者：
Lappas, M;Permezel, M;Rice, GE
通讯作者：
Rice, GE
影响因子：
3.5
作者：
Colomiere, Michelle;Permezel, Michael;Lappas, Martha
通讯作者：
Lappas, Martha