DNA methylation in endometrial cancer.
DNA methylation in endometrial cancer.
复制标题
子宫内膜癌中的 DNA 甲基化。
DOI：
10.4161/epi.5.6.12431
复制
发表时间：
2010-08-16
期刊：
影响因子：
3.7
通讯作者：
Freudenheim, Jo L.
中科院分区：
文献类型：
--
作者：
Tao, Meng Hua;Freudenheim, Jo L.
Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic, and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is aberrant DNA methylation. In this review, we review evidence on the role of aberrant DNA methylation, examining changes in relation to endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to endometrial cancer with the emphasis on the role of dietary/lifestyle and environmental factors, as well as opportunities and challenges of DNA methylation in endometrial cancer management and prevention.
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影响因子：
4.2
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通讯作者：
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通讯作者：
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