Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.
Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.
复制标题
偏侧忽视中风患者白质对视觉空间注意力贡献的博弈论映射。
DOI：
10.1002/hbm.24987
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发表时间：
2020
影响因子：
4.8
通讯作者：
Valero-Cabré,Antoni
中科院分区：
文献类型：
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作者：
Toba,MonicaN;Zavaglia,Melissa;Malherbe,Caroline;Moreau,Tristan;Rastelli,Federica;Kaglik,Anna;Valabrègue,Romain;Pradat-Diehl,Pascale;Hilgetag,ClausC;Valero-Cabré,Antoni
连接灰质节点的白色物质束是充分表征大脑系统和认知功能之间关联的关键解剖学参与者。在这里，我们使用了基于联盟博弈论（多扰动Shapley值分析，MSA）的多变量病变推断方法来推断白色物质束对注意力视觉空间定向的因果贡献。我们的工作是基于对25例右半球卒中患者的损伤模式的表征以及它们对三项神经心理学任务的影响的因果分析：线平分、字母取消和铃声取消。我们报告说，在我们的MSA联盟中包括的11个白色物质束中，视辐射、额枕下束和前扣带束是唯一显示任务不变贡献（分别为正、正和负）的束。我们还报告了任务依赖性的影响，分支的上级纵束和后扣带。通过将先前的研究结果扩展到连接关键灰质节点的白色物质束，我们从网络的角度进一步表征了视觉和注意定向过程的解剖学基础。通过进一步的研究，巩固了由连接注意力定向网络的皮质节点的白色物质束介导的相互作用模式的知识，可能有助于开发和定制用于视觉空间忽视康复的脑刺激方法。
White matter bundles linking gray matter nodes are key anatomical players to fully characterize associations between brain systems and cognitive functions. Here we used a multivariate lesion inference approach grounded in coalitional game theory (multiperturbation Shapley value analysis, MSA) to infer causal contributions of white matter bundles to visuospatial orienting of attention. Our work is based on the characterization of the lesion patterns of 25 right hemisphere stroke patients and the causal analysis of their impact on three neuropsychological tasks:line bisection,letter cancellation, andbells cancellation. We report that, out of the 11 white matter bundles included in our MSA coalitions, the optic radiations, the inferior fronto‐occipital fasciculus and the anterior cingulum were the only tracts to display task‐invariant contributions (positive, positive, and negative, respectively) to the tasks. We also report task‐dependent influences for the branches of the superior longitudinal fasciculus and the posterior cingulum. By extending prior findings to white matter tracts linking key gray matter nodes, we further characterize from a network perspective the anatomical basis of visual and attentional orienting processes. The knowledge about interactions patterns mediated by white matter tracts linking cortical nodes of attention orienting networks, consolidated by further studies, may help develop and customize brain stimulation approaches for the rehabilitation of visuospatial neglect.