The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours
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DOI：
10.1016/j.eururo.2016.02.029
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发表时间：
2016-07-01
期刊：
影响因子：
23.4
通讯作者：
Ulbright, Thomas M.
中科院分区：
文献类型：
--
作者：
Moch, Holger;Cubilla, Antonio L.;Ulbright, Thomas M.
2016年出版的世界卫生组织（WHO）第四版泌尿生殖系统肿瘤分类（WHO“蓝皮书”）包含了重大修订。这些修订是由在该领域具有特殊专业知识的一个大型国际病理学家小组审议后进行的。其中一个分组于2015年在瑞士苏黎世举行的世卫组织共识会议上会面，以最终确定这些修订。本综述总结了新发布的分类与之前版本在肾、阴茎和睾丸肿瘤方面最显著的差异。新确认的上皮性肾肿瘤包括遗传性平滑肌瘤病和肾细胞癌（RCC）综合征相关肾细胞癌、琥珀酸脱氢酶缺陷型肾细胞癌、管状囊性肾细胞癌、获得性囊性疾病相关肾细胞癌以及透明细胞乳头状肾细胞癌。推荐使用世卫组织/国际泌尿病理学会肾肿瘤分级系统，并且肾乳头状腺瘤的定义已被修改。新的世卫组织阴茎鳞状细胞癌分类基于人乳头瘤病毒的存在，并相应地定义了组织学亚型。睾丸原位生殖细胞瘤变（GCNIS）是世卫组织推荐的用于侵袭性生殖细胞肿瘤前驱病变的术语，并且睾丸生殖细胞肿瘤现在被分为两个根本不同的组：源自GCNIS的和与GCNIS无关的。精母细胞性精原细胞瘤在2016年世卫组织分类中被指定为精母细胞性肿瘤，并被归入非GCNIS相关肿瘤组。患者总结：2016年世界卫生组织分类包含新的肾肿瘤病种。阴茎鳞状细胞癌的分类基于人乳头瘤病毒的存在。睾丸原位生殖细胞瘤变是世卫组织推荐的用于侵袭性生殖细胞肿瘤前驱病变的术语。（C）2016年欧洲泌尿外科学会。由爱思唯尔出版集团出版。保留所有权利。
The fourth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "blue book"), published in 2016, contains significant revisions. These revisions were performed after consideration by a large international group of pathologists with special expertise in this area. A subgroup of these persons met at the WHO Consensus Conference in Zurich, Switzerland, in 2015 to finalize the revisions. This review summarizes the most significant differences between the newly published classification and the prior version for renal, penile, and testicular tumours. Newly recognized epithelial renal tumours are hereditary leiomyomatosis and renal cell carcinoma (RCC) syndrome-associated RCC, succinate dehydrogenase-deficient RCC, tubulocystic RCC, acquired cystic disease-associated RCC, and clear cell papillary RCC. The WHO/International Society of Urological Pathology renal tumour grading system was recommended, and the definition of renal papillary adenoma was modified. The new WHO classification of penile squamous cell carcinomas is based on the presence of human papillomavirus and defines histologic subtypes accordingly. Germ cell neoplasia in situ (GCNIS) of the testis is the WHO-recommended term for precursor lesions of invasive germ cell tumours, and testicular germ cell tumours are now separated into two fundamentally different groups: those derived from GCNIS and those unrelated to GCNIS. Spermatocytic seminoma has been designated as a spermatocytic tumour and placed within the group of non-GCNIS-related tumours in the 2016 WHO classification. Patient summary: The 2016 World Health Organization (WHO) classification contains new renal tumour entities. The classification of penile squamous cell carcinomas is based on the presence of human papillomavirus. Germ cell neoplasia in situ of the testis is the WHO-recommended term for precursor lesions of invasive germ cell tumours. (C) 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.