Interaction of estrogen and gonadotrophins on follicular atresia.
Interaction of estrogen and gonadotrophins on follicular atresia.
复制标题
雌激素和促性腺激素对卵泡闭锁的相互作用。
作者：
S. Harman;J. Louvet;G. Ross
我们研究了卵泡闭锁，给予垂体切除的未成熟雌性大鼠（HIFR）二乙基己烯雌酚或促性腺激素与或不与化学抗雌激素CI-628，使正常和闭锁卵泡的总计数大于125 μ M的直径，并使用一个简单的模型来分析数据。我们的研究结果表明，雌激素的抗闭锁作用，独立于其良好的有丝分裂作用的腔前卵泡。我们还表明，CI-628作为抗雌激素阻断卵泡增殖，同时作为雌激素抑制闭锁。此外，我们观察到促性腺激素引起的闭锁增加，与雌激素介导的卵泡生长的积极作用相反。
We have investigated folluclar atresia by giving hypophysectomized immature female rats (HIFR) diethylstibestrol or gonadotrophins with and without the chemical antiestrogen CI-628, making total counts of normal and atretic follicles greater than 125 muM in diameter, and using a simple model to analyze data. Our results show an antiatretic effect of estrogen, independent of its well-documented mitogenic effect on preantral follicles. We have also shown that CI-628 acts as an anti-estrogen to block follicular proliferation, while acting as an estrogen to inhibit atresia. In addition, we have observed an increase in atresia caused by gonadotrophins, in opposition to their estrogen-mediated positive effect on follicular growth.