IGF-1 regulation of key signaling pathways in bone.
IGF-1 regulation of key signaling pathways in bone.
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DOI：
10.1038/bonekey.2013.171
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发表时间：
2013-10-02
期刊：
影响因子：
--
通讯作者：
Rosen, Clifford J
中科院分区：
文献类型：
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作者：
Guntur, Anyonya R;Rosen, Clifford J
胰岛素样生长因子1 （IGF-1）是一种在大多数组织中以内分泌/旁分泌和自分泌方式起作用的独特肽。虽然最初假设肝脏来源的IGF-1是IGF-1的主要来源（即生长激素假说），但它也在各种组织中产生，并可以以多种方式作为增殖因子和分化因子发挥作用。骨骼就是这样的一个组织，骨骼中的所有细胞系不仅需要IGF-1来维持正常的发育和功能，而且还通过IGF-1受体对IGF-1做出反应。配体受体的激活导致了几种不同的下游信号级联反应，这些信号级联反应对细胞存活、蛋白质合成和能量利用具有重要意义。IGF-1在调节骨重塑单位代谢需求中的新作用目前正在研究中。更多的研究可能会揭示骨骼生理学的各个方面，并可能导致新的治疗方法。
Insulin-like growth factor 1 (IGF-1) is an unique peptide that functions in an endocrine/paracrine and autocrine manner in most tissues. Although it was postulated initially that liver-derived IGF-1 was the major source of IGF-1 (that is, the somatomedin hypothesis), it is also produced in a wide variety of tissues and can function in numerous ways as both a proliferative and differentiative factor. One such tissue is bone and all cell lineages in the skeleton have been shown to not only require IGF-1 for normal development and function but also to respond to IGF-1 via the IGF-1 receptor. Ligand-receptor activation leads to several distinct downstream signaling cascades, which have significant implications for cell survival, protein synthesis and energy utilization. The novel role of IGF-1 in regulating metabolic demands of the bone remodeling unit is currently under investigation. More studies are likely to shed new light on various aspects of skeletal physiology and potentially may lead to new therapeutics.