Human protein reference database as a discovery resource for proteomics
Human protein reference database as a discovery resource for proteomics
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DOI：
10.1093/nar/gkh070
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Pandey, A
中科院分区：
文献类型：
--
作者：
Peri, S;Navarro, JD;Pandey, A
基因组和蛋白质组数据的快速生成，使得开发用于管理数据的工具和资源成为必要，这些工具和资源要能整合来自不同来源的信息。人类蛋白质参考数据库（http://www.hprd.org）是一个基于开源技术的网络资源，提供有关人类蛋白质多个方面的信息，包括蛋白质 - 蛋白质相互作用、翻译后修饰、酶 - 底物关系以及疾病关联。这些信息是由专业生物学家通过对已发表文献的严谨阅读以及对蛋白质序列的生物信息学分析手动获取的。该数据库将作为基因组和蛋白质组信息的资源，并提供健康和疾病状态下序列、结构、功能和蛋白质网络的综合视图，从而有助于生物医学的发现。
The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein Reference Database (http://www.hprd.org) is a web-based resource based on open source technologies for protein information about several aspects of human proteins including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. This information was derived manually by a critical reading of the published literature by expert biologists and through bioinformatics analyses of the protein sequence. This database will assist in biomedical discoveries by serving as a resource of genomic and proteomic information and providing an integrated view of sequence, structure, function and protein networks in health and disease.