Differential symptom reduction by drugs and psychotherapy in acute depression.
Differential symptom reduction by drugs and psychotherapy in acute depression.
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急性抑郁症通过药物和心理治疗减轻不同症状。
DOI：
10.1001/archpsyc.1979.01780130068008
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发表时间：
1979
影响因子：
--
通讯作者：
G. Klerman
中科院分区：
文献类型：
--
作者：
A. Dimascio;Myrna M. Weissman;B. Prusoff;C. Neu;Maggie Zwilling;G. Klerman
一项随机对照试验比较了阿米替林和短期人际心理疗法的组合，无论是单独治疗，还是非计划治疗对照组，对非精神病型急性抑郁症患者进行了比较。结果表明，心理治疗和阿米替林在总体症状减轻方面均有疗效。阿米替林和心理疗法大致相同，两种疗法的联合作用是相加的。复合处理的相加效应很大程度上是由于两个处理的不同效应。阿米替林主要作用于抑郁症的植物症状，如睡眠和食欲障碍，这些症状发生在治疗的早期，通常在第一周内。心理治疗主要对情绪、自杀意念、工作和兴趣产生影响；这些影响发生的时间稍晚，在4到8周。
A randomized, controlled trial compared the combination of amitriptyline hydrochloride and short-term interpersonal psychotherapy, either treatment alone, and a nonscheduled treatment control group in ambulatory acute, nonbipolar, nonpsychotic depressives. Results show the efficacy of both psychotherapy and amitriptyline in overall symptom reduction. Amitriptyline and psychotherapy were about equal, and the effects of both treatments in combination were additive. The additive effect of combined treatment was largely due to the differential effects of the two treatments. Amitriptyline had its effect mainly on the vegetative symptoms of depression such as sleep and appetite disturbance, these occurred early in treatment, often within the first week. Psychotherapy had its effect mainly on mood, suicidal ideation, work, and interests; these effects occurred slightly later, at four to eight weeks.