Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study
Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study
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较长的妊娠间隔和不良的围产期结局：一项回顾性队列研究
DOI：
10.1007/s11427-018-9593-8
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发表时间：
2019-11-05
影响因子：
9.1
通讯作者：
Huang, He-Feng
中科院分区：
文献类型：
--
作者：
Lin, Jing;Liu, Han;Huang, He-Feng
我们对2014至2016年间在国际和平妇幼保健院经历二次分娩的9,552名妇女进行了一项回溯性队列研究，以调查口译间隔(IPI)与不良围产期结果之间的关系。以12~23个月胎盘指数为参考值，采用Logistic回归分析探讨不同胎盘指数(12、12~23、24~59、60~119和≥120个月)与围产儿结局(妊娠期糖尿病、胎膜早破、妊娠期高血压、早产、低出生体重儿、巨大儿)的关系。与IPI12~23个月组相比，IPI>12~23个月的孕妇发生不良围产儿结局的风险较高，IPI>120个月的孕妇发生妊娠期糖尿病和胎膜早破的风险最高(调整后的优势比(OR)为1.76，95%可信区间(CI)为1.32~2.35，调整后的OR值为2.03，95%CI为1.53~2.67)。这些结果表明，IPI越长，围产儿结局不良的风险越高，而≥为120MON的IPI似乎独立地与妊娠期糖尿病和胎膜早破的风险相关。
We conducted a retrospective cohort study of 9,552 women experiencing their second delivery between 2014 and 2016 at the International Peace Maternity and Child Health Hospital to investigate the association between the interpregnancy interval (IPI) and adverse perinatal outcomes. With the 12–23-mon IPI as the reference category, logistic regression analyzes were used to examine associations between different IPIs (<12, 12–23, 24–59, 60–119, and ≥120 mon) and perinatal outcomes (gestational diabetes mellitus, premature membrane rupture, gestational hypertension, preterm birth, low birth weight, and macrosomia). Compared with the 12–23-mon IPI category, women with longer IPIs had a higher risk of adverse perinatal outcomes, and those with an IPI ≥120 mon had the highest risk of gestational diabetes mellitus and premature membrane rupture (adjusted odds ratio (OR) 1.76, 95% confidence interval (CI) 1.32–2.35 and adjusted OR 2.03, 95% CI 1.53–2.67, respectively). These results indicate that a longer IPI is associated with a higher risk of adverse perinatal outcomes and an IPI of ≥120 mon appears to be independently associated with a higher risk of gestational diabetes mellitus and premature membrane rupture.