Importance of immune deviation toward Th1 in the early immunopathogenesis of human T-lymphotropic virus type I-associated myelopathy.
Importance of immune deviation toward Th1 in the early immunopathogenesis of human T-lymphotropic virus type I-associated myelopathy.
复制标题
Th1 免疫偏差在人类 T 淋巴细胞病毒 I 型相关脊髓病的早期免疫发病机制中的重要性。
DOI：
10.1054/mehy.1999.0949
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发表时间：
2000
影响因子：
4.7
通讯作者：
K. Eguchi
中科院分区：
文献类型：
--
作者：
T. Nakamura;T. Furuya;Y. Nishiura;K. Ichinose;S. Shirabe;K. Eguchi
虽然人嗜T淋巴细胞病毒I型（HTLV-I）相关性脊髓病（HAM）的主要神经病理学特征是脊髓慢性炎症，其特征为单核细胞血管周围形成袖套并伴有实质淋巴细胞浸润，但HTLV-I感染引起脊髓慢性炎症的确切机制仍不清楚。在HAM患者中，外周血CD 4（+）T淋巴细胞，特别是HTLV-I感染的CD 4（+）T淋巴细胞，与内皮细胞的粘附活性和穿过基底膜的迁移活性增加。此外，细胞因子表达谱提示HAM患者外周血CD 4（+）T淋巴细胞中Th 1细胞数量增加。这些发现强烈地表明，免疫偏向Th 1，这可能是基于高病毒载量的HTLV-I，在HAM患者中枢神经系统的组织损伤中起着重要作用。我们在此强调活化的Th 1细胞作为HAM免疫发病机制中的第一触发器的重要性。
Although the principal neuropathological feature of human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) is chronic inflammation of the spinal cord, characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration, the precise mechanisms by which HTLV-I infection causes chronic inflammation of the spinal cord are still obscure. In patients with HAM, peripheral blood CD4(+)T lymphocytes, particularly HTLV-I-infected CD4(+)T lymphocytes, have increased adherent activity to endothelial cells and transmigrating activity through basement membranes. In addition, the profile of cytokine expression suggests increased numbers of Th1 cells in peripheral blood CD4(+)T lymphocytes of patients with HAM. These findings strongly suggest that immune deviation toward Th1, which might be based on high viral load of HTLV-I, plays an important role in tissue damage in the central nervous system of patients with HAM. We herein emphasize the importance of activated Th1 cells as the first trigger in the immunopathogenesis of HAM.