Synthesis and synergetic effects of chrysin-organogermanium (IV) complex as potential anti-oxidant
Synthesis and synergetic effects of chrysin-organogermanium (IV) complex as potential anti-oxidant
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DOI：
10.1016/j.bmcl.2013.07.073
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发表时间：
2013-10-15
影响因子：
2.7
通讯作者：
Cai, Jiye
中科院分区：
文献类型：
--
作者：
Jiang, Jinhuan;Yao, Shuguang;Cai, Jiye
有机锗（IV）（Ge）被认为在某些中药的抗氧化活性中起重要作用。本文合成了一种新的白杨素-有机锗（Chry-Ge）配合物，并对其潜在的生物活性进行了研究。通过在有机锗和有机铬的配合物中引入自由基敏感的Ge-O键，提高了有机锗和有机铬的生物活性。结果表明，金锗配合物具有较强的抗氧化活性，其清除羟自由基的能力强于相应的配体。我们还证明了Chry-Ge复合物抑制ROS依赖的细胞氧化损伤。此外，在氧化损伤的细胞诱导的形态和生物物理的恢复，由原子力显微镜表征的Chry-Ge络合物。这些结果表明，金锗配合物具有协同清除自由基的作用，可作为一种有前途的抗氧化剂。(C)2013爱思唯尔有限公司保留所有权利。
Organogermanium(IV) (Ge) is considered to play an important role in the anti-oxidative activities of some Chinese medicines. Here, a new chrysin-organogermanium (Chry-Ge) complex was synthesized and investigated for its potential biological activities. The radicals-sensitive Ge-O bond was introduced to Chry-Ge complex to enhance bioactivities of organic Ge or Chry. Results showed that Chry-Ge complex possessed great anti-oxidative activities, showing stronger hydroxyl scavenging effects than their corresponding ligands. We also demonstrated Chry-Ge complex inhibited ROS-dependent oxidative damage in cells. Moreover, the morphological and biophysical recoveries in oxidation-damaged cells induced by Chry-Ge complex were characterized by atomic force microscopy. All these results collectively suggested that Chry-Ge complex has synergetic effect for radicals scavenging and could be served as promising pharmacologically active agent against anti-oxidative treatment. (C) 2013 Elsevier Ltd. All rights reserved.