Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis.
Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis.
复制标题
胶质瘤的分子分类与癫痫控制相关：一项回顾性分析。
DOI：
10.1007/s12017-020-08624-0
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发表时间：
2021-06
影响因子：
3.5
通讯作者：
Dey M
中科院分区：
文献类型：
--
作者：
Easwaran TP;Lancki N;Henriquez M;Vortmeyer AO;Barbaro NM;Scholtens DM;Ahmed AU;Dey M
胶质瘤的经典组织学分级已被用于预测癫痫发作相关性，与高级别胶质瘤相比，低级别胶质瘤与癫痫发作发生率增加相关。2016年，世卫组织根据组织学和分子特征对胶质瘤进行了重新分类。我们试图确定胶质瘤的分子分类是否与多种胶质瘤亚型的术前癫痫发作表现和/或术后癫痫发作控制相关。2007-2017年在我们机构手术的所有神经胶质瘤均根据ICD 9和10计费代码进行识别，并回顾性评估IDH 1突变和1 p/19 q共缺失的分子分类。Logistic回归模型进行评估协会的癫痫发作在介绍以及术后癫痫发作IDH状态和新的WHO综合分类。我们的研究包括376例患者：82例IDH突变型和294例IDH野生型。IDH突变的存在与癫痫发作相关[OR=3.135（1.818-5.404），p<0.001]。IDH突变型胶质母细胞瘤的癫痫发作频率低于其他IDH突变型胶质瘤亚型II级和III级[OR=0.104（0.032-0.340），p<0.001]。经Engel分级证实，IDH突变型肿瘤与更差的术后癫痫结局相关[OR 2.666（1.592-4.464），p<0.001]。胶质瘤中IDH突变与癫痫发作发展风险增加和术后癫痫控制不良相关，除GBM外，所有级别均如此。
Classically histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016 WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular classification of gliomas is associated with pre-operative seizure presentation and/or post-operative seizure control across multiple glioma subtypes. All gliomas operated at our institution from 2007–2017 were identified based on ICD 9 and 10 billing codes and were retrospectively assessed for molecular classification of the IDH1 mutation, and 1p/19q codeletion. Logistic regression models were performed to assess associations of seizures at presentation as well as post-operative seizures with IDH status and the new WHO integrated classification. Our study included 376 patients: 82 IDH mutant and 294 IDH wildtype. Presence of IDH mutation was associated with seizures at presentation [OR=3.135 (1.818–5.404), p<0.001]. IDH-mutant glioblastomas presented with seizures less often than other IDH-mutant glioma subtypes grade II and III [OR=0.104 (0.032–0.340), p<0.001]. IDH-mutant tumors were associated with worse post-operative seizure outcomes, demonstrated by Engel Class [OR 2.666 (1.592–4.464), p<0.001]. IDH mutation in gliomas is associated with an increased risk of seizure development and worse post-operative seizure control, in all grades except for GBM.
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影响因子：
4.1
作者：
Chang, Edward F.;Potts, Matthew B.;Berger, Mitchel S.
通讯作者：
Berger, Mitchel S.
影响因子：
5.2
作者：
Ius, Tamara;Pauletto, Giada;Skrap, Miran
通讯作者：
Skrap, Miran
影响因子：
4.3
作者：
Brogna, Christian;Gil Robles, Santiago;Duffau, Hugues
通讯作者：
Duffau, Hugues
影响因子：
5.6
作者：
Perucca, Emilio
通讯作者：
Perucca, Emilio
影响因子：
5.6
作者：
Englot, Dario J.;Berger, Mitchel S.;Chang, Edward F.
通讯作者：
Chang, Edward F.