PHYSICAL ASPECTS OF THE GROWTH AND REGULATION OF MICROTUBULE STRUCTURES
PHYSICAL ASPECTS OF THE GROWTH AND REGULATION OF MICROTUBULE STRUCTURES
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DOI：
10.1103/physrevlett.70.1347
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发表时间：
1993-03-01
影响因子：
8.6
通讯作者：
LEIBLER, S
中科院分区：
文献类型：
--
作者：
DOGTEROM, M;LEIBLER, S
通过所谓的动力学不稳定性的微管的生长进行了分析，在一个简单的理论模型中，聚合物成核的一个平面。对于一个孤立的微管模型预测有界和无界增长之间的过渡的存在。它还表明，这种转变改变了密集结构的组装，例如，通过极大地限制从表面生长的长微管的数量。再加上生长的微观生化控制，这种物理效应似乎在调节细胞结构（如有丝分裂纺锤体）的形成中发挥重要作用。
The growth of microtubules through the so-called dynamical instability is analyzed within a simple theoretical model in which the polymers are nucleated by a flat surface. For an isolated microtubule the model predicts the existence of a transition between bounded and unbounded growth. It is also shown that this transition alters the assembly of dense structures, e.g., by drastically limiting the number of long microtubules grown from the surface. Coupled to the microscopic biochemical control of the growth, such physical effects seem to play an important role in the regulation of the formation of cellular structures (such as the mitotic spindle).