PROSTATE‐SPECIFIC ACID PHOSPHATASE VERSUS ACID PHOSPHATASE IN MONITORING PATIENTS WITH PROSTATE CANCER *
PROSTATE‐SPECIFIC ACID PHOSPHATASE VERSUS ACID PHOSPHATASE IN MONITORING PATIENTS WITH PROSTATE CANCER *
复制标题
前列腺特异性酸性磷酸酶与酸性磷酸酶在监测前列腺癌患者中的比较 *
DOI：
--
复制
发表时间：
1982
影响因子：
5.2
通讯作者：
T. Chu
中科院分区：
文献类型：
--
作者：
C. Killian;F. Vargas;N. Slack;G. Murphy;T. Chu
比较了57例早期前列腺癌患者和33例晚期前列腺癌患者的PAP和AcP活性序列水平的相对价值。一些关于患者疾病状态和酶水平的发现可能对这些患者的治疗管理有益。它们是：b[1]，在疾病复发和疾病进展中PAP活性升高通常先于AcP活性升高，因此对于早期和晚期疾病患者来说是一个更敏感的指标；[2]连续平均PAP活性水平大于平均值+ 3 SD比AcP活性水平在两组患者中更能预测疾病的复发和进展；[3] PAP活性比AcP活性更能灵敏地监测客观治疗反应的变化；b[4] PAP对前列腺的特异性比AcP更高，因此为鉴别来源不明的转移，或确认可能由其他非前列腺特异性标志物提示的原发性前列腺肿瘤转移提供了更可靠的标志物[s]。此外，数据显示接受治疗的患者预后良好，这是由PAP活性的系列平均值小于平均值+ 3 SD推断的。
Serial levels of PAP and AcP activity were compared for their relative values in monitoring 57 early and 33 advanced prostate cancer patients. Several findings regarding the patients' disease status and the enzyme levels have been observed that may be beneficial to therapeutic management of these patients. They are: [1] an elevated PAP activity in disease recurrence and disease progression generally precedes an elevated AcP activity, and thus represents a more sensitive index for patients with early and advanced disease; [2] serial mean levels of PAP activity greater than the mean + 3 SD are more predictive for disease recurrence and progression than are those of AcP activity in both groups of patients; [3] PAP activity is a more sensitive monitor for changes in objective treatment response than is AcP activity; and [4] PAP is more specific than AcP for prostate, thus offering a more reliable marker to identify metastasis of unknown origin, or to confirm metastasis derived from a primary prostate tumor that may have been suggested by other non-prostate-specific marker[s]. In addition, data suggest a favorable prognosis for patients receiving therapy as inferred by a serial mean of PAP activity that is less than mean + 3 SD.
前列腺酸性磷酸酶的定量反免疫电泳测定。
DOI：
--
发表时间：
1980
期刊：
Investigative urology
影响因子：
--
作者：
Killian,CS;Vargas,FP;Lee,CL;Wang,MC;Murphy,GP;Chu,TM
通讯作者：
Chu,TM
使用组织特异性抗原对人类前列腺癌进行多重标记物评估。
DOI：
--
发表时间：
1982
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Kuriyama,M;Wang,MC;Lee,CL;Killian,CS;Papsidero,LD;Inaji,H;Loor,RM;Lin,MF;Nishiura,T;Slack,NH;Murphy,GP;Chu,TM
通讯作者：
Chu,TM