Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
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DOI：
10.1016/j.tet.2013.03.050
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发表时间：
2013-05-13
期刊：
影响因子：
2.1
通讯作者：
Niwa, Haruki
中科院分区：
文献类型：
--
作者：
Iwano, Satoshi;Obata, Rika;Niwa, Haruki
开发了发射蓝光、绿色和红光的简单萤火虫荧光素类似物。在675 nm处观察到最长的发射最大值，其属于NIR生物窗口（650-900 nm），可用于活体动物的深层生物成像。类似物显示出缓慢上升的发射强度相比，快速发射的天然甜菜碱。腺苷酸化类似物的光发射与类似物本身相比强烈增强。(C)2013爱思唯尔有限公司保留所有权利。
Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650-900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves. (C) 2013 Elsevier Ltd. All rights reserved.