Ethnic differences in the relationship between adiponectin and insulin sensitivity in south Asian and Caucasian women
Ethnic differences in the relationship between adiponectin and insulin sensitivity in south Asian and Caucasian women
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DOI：
10.2337/dc07-1781
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发表时间：
2008-04-01
期刊：
影响因子：
16.2
通讯作者：
Reaven, Peter D.
中科院分区：
文献类型：
--
作者：
Martin, Marlene;Palaniappan, Latha P.;Reaven, Peter D.
目的 - 评估南亚印度人较低的脂联素浓度是否可能导致其较高程度的胰岛素抵抗。研究设计和方法 - 对 52 名南亚 (SA) 和高加索 (CAU) 血统女性的胰岛素介导的葡萄糖摄取以及血浆总脂联素和高分子量 (HMW) 脂联素浓度进行量化并进行比较。结果 - 平均值 +/- SD 总计 (2,965 +/- SA 中的脂联素为 1,278 与 4,235 +/- 160 ng/ml）和 HMW（1,001 +/- 352 与 1,591 +/- 854 ng/ml）脂联素低于 CAU（P < 0.005）。胰岛素抵抗性 CAU (CAU-IR) 的脂联素总量（2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml）和 HMW（987 +/- 479 vs. 1,935 +/- 838 ng/ml）脂联素低于胰岛素敏感性 CAU (CAU-IS) (P < 0.01)，但无显着性差异。胰岛素抵抗 (SA-IR) 和胰岛素敏感 (SA-IS) SAS 之间的差异。 SA-IR 和 CAU-IR 之间的 HMW 脂联素没有差异，但 SA-IS 的脂联素浓度显着低于 CAU-IS。结论 - 与 CAU 女性相比，这些 SA 女性的胰岛素抵抗状态与脂联素水平显着降低无关。
OBJECTIVE - To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance.RESEARCH DESIGN AND METHODS - insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared.RESULTS - Mean +/- SD total (2,965 +/- 1,278 vs. 4,235 +/- 160ng/ml) and HMW(1,001 +/- 352 vs. 1,591 +/- 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml) and HMW (987 +/- 479 vs. 1,935 +/- 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAS. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS.CONCLUSIONS - Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.