Prenatal organophosphate pesticide exposure and reproductive hormones in cord blood in Shandong, China
Prenatal organophosphate pesticide exposure and reproductive hormones in cord blood in Shandong, China
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中国山东省产前有机磷农药暴露及脐带血生殖激素
DOI：
10.1016/j.ijheh.2020.113479
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发表时间：
2020
影响因子：
6
通讯作者：
Gao Yu
中科院分区：
文献类型：
--
作者：
Qin Kaili;Zhang Yan;Wang Yiwen;Shi Rong;Pan Rui;Yao Qian;Tian Ying;Gao Yu
研究背景有机磷农药(OPs)与内分泌紊乱有关，但对母亲暴露于Op与胎儿生殖激素水平之间的关系进行了有限的研究。本研究探讨孕期OP暴露与胎儿生殖激素的关系。方法选择2010年9月至2012年2月的306名健康孕妇。通过分析母亲尿中有机磷农药(DAP)的非特异性代谢物来评估农药暴露，并测定脐带血中四种生殖激素。用线性回归模型和广义线性模型估计二乙基磷酸代谢产物与生殖激素的关系，并按婴儿性别进行分层。结果二乙基磷酸(DEP)浓度与雌二醇(E2)呈负相关(β=−0.0 3；95%CI：−0.0 7，−0.0 0)。二甲基磷酸盐(β=−0.08；95%CI：−0.13，−0.03)、二乙基硫代磷酸(β=−0.08；95%CI：−0.14，−0.01)和DAP(β=0.10；95%CI：−0.17，−0.03)与睾酮(T)水平呈负相关。DMP与卵泡刺激素水平呈负相关(β=−0.03；95%CI：−0.05，−0.01)。DMP(β=−0.0 6；95%CI：−0.10，−0.0 1)和DETP(β−=0.0 7；95%CI：−0.13，−0.0 1)与睾酮/雌二醇(T/E 2)呈负相关。此外，相关性的大小在浓度较高的四分位数中以剂量-反应方式显著增加。按性别分层后，这些影响主要在女婴中观察到。结论产前OP暴露对胎儿生殖激素的潜在影响，可能存在性别差异。
BackgroundOrganophosphate pesticides (OPs) have been found to be associated with endocrine disorders, but limited research has been conducted to evaluate the relationship between maternal OP exposure and fetal reproductive hormone levels. In this study, we investigated the association between prenatal OP exposure and fetal reproductive hormones.MethodsA total of 306 healthy pregnant women were enrolled between September 2010 and February 2012. Pesticide exposure was assessed via the analysis of maternal urinary nonspecific metabolites of OPs (dialkylphosphate, DAP), and four reproductive hormones were measured in cord blood. Linear regression models and generalized linear models were used to estimate the associations between DAP metabolites and reproductive hormones, and further stratified by infant sex.ResultsWe found that concentrations of diethylphosphate (DEP) (β = −0.03; 95% CI: −0.07, −0.00) were inversely associated with estradiol (E2). Dimethylphosphate (DMP) (β = −0.08; 95% CI: −0.13, −0.03), diethylthiophosphate (DETP) (β = −0.08; 95% CI: −0.14, −0.01), and DAPs (β = −0.10; 95% CI: −0.17, −0.03) were inversely associated with testosterone (T) levels. DMP was inversely associated with follicle-stimulating hormone (FSH) levels (β = −0.03; 95% CI: −0.05, −0.01). DMP (β = −0.06; 95% CI: −0.10, −0.01) and DETP (β = −0.07; 95% CI: −0.13, −0.01) showed inverse associations with the testosterone/estradiol (T/E2) ratio. Moreover, the magnitude of associations notably increased in higher quartiles of concentrations in a dose-response manner. After stratification by sex, these effects were mainly observed among female infants.ConclusionOur findings suggest the potential impacts of prenatal OP exposure on fetal reproductive hormones, and that sex-related differences may exist.