Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye
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DOI：
10.1080/23723556.2020.1777060
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发表时间：
2020-06-24
影响因子：
2.1
通讯作者：
Tannir, Nizar M.
中科院分区：
文献类型：
--
作者：
Msaouel, Pavlos;Walker, Cheryl L.;Tannir, Nizar M.
肾髓样癌(RMC)是一种主要困扰具有镰状细胞特征的年轻人的致命性疾病。我们最近报道的未经治疗的原发RMC组织的分子图谱阐明了RMC的独特基因组和免疫特征，并确定MYC诱导的复制应激是这种疾病的靶向易损性。
Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.