Kidney ultrasound findings according to kidney function in sickle cell anemia.
Kidney ultrasound findings according to kidney function in sickle cell anemia.
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根据镰状细胞性贫血肾功能的肾脏超声检查结果。
DOI：
10.1002/ajh.25602
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发表时间：
2019
影响因子：
12.8
通讯作者：
Saraf,SantoshL
中科院分区：
文献类型：
--
作者：
Patel,Rishi;Kang,Sandra;Valeshabad,AliKord;Shah,BinalN;Han,Jin;Gowhari,Michel;Molokie,RobertE;Xie,Karen;Lash,JamesP;Gordeuk,VictorR;Saraf,SantoshL
高达60%的镰状细胞性贫血（SCA）成人有慢性肾脏疾病（CKD）的证据我们假设肾脏超声测量回声强度和大小可以作为SCA患者CKD的非侵入性预后指标。在伊利诺伊大学芝加哥分校接受超声检查作为常规护理一部分的SCA患者中，纵向随访的所有177例SCA患者中，肾脏回声增强是CKD进展的独立预测因素，在超声检查时肾脏功能正常的104例患者和因非肾脏指征接受超声检查的96例患者中也是如此。肾活检与出血风险相关，在SCA患者中很少进行，但肾超声检查是非侵入性的，安全且广泛可用。在非sca队列中，肾脏回声增强与小管间质损伤、肾小球硬化、[2]和估计肾小球滤过率（eGFR）降低相关肾小与一些组织病理学改变有关，但不能一致地预测肾功能在SCA中有肾脏超声异常的发现，15-30%的患者肾脏增大，10-18%的患者肾脏增大
Up to 60% of sickle cell anemia (SCA) adults have evidence of chronic kidney disease (CKD).[1] We hypothesized that kidney ultrasound measures of echogenicity and size may serve as a non-invasive prognostic markers for CKD in SCA. Among University of Illinois at Chicago SCA patients who received ultrasounds as part of routine care, increased kidney echogenicity was an independent predictor of CKD progression among all 177 SCA patients with longitudinal follow up as well as in the subset of 104 with normal kidney function at the time of the ultrasound and 96 who had ultrasounds performed for non-renal indications.Kidney biopsy is associated with a risk for bleeding and is infrequently performed in patients with SCA but renal ultrasonography is non-invasive, safe and widely available. In non-SCA cohorts, kidney echogenicity correlates with tubulointerstitial damage, glomerulosclerosis,[2] and reduced estimated glomerular filtration rate (eGFR).[3] Small kidney size correlates with some histopathologic changes [2] but does not consistently predict kidney function.[3] Abnormal kidney ultrasound findings have been described in SCA, with 15–30% of patients having enlarged kidneys and 10–18% having increased
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