CELL-DEATH IN THE RETINAL GANGLION-CELL LAYER DURING OPTIC-NERVE REGENERATION FOR THE FROG RANA-PIPIENS
CELL-DEATH IN THE RETINAL GANGLION-CELL LAYER DURING OPTIC-NERVE REGENERATION FOR THE FROG RANA-PIPIENS
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DOI：
10.1016/0042-6989(86)90003-9
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发表时间：
1986-01-01
期刊：
影响因子：
1.8
通讯作者：
PERRY, VH
中科院分区：
文献类型：
--
作者：
BEAZLEY, LD;DARBY, JE;PERRY, VH
从甲酚染色的整体计数中估计成年尖音蛙视网膜神经节细胞层中的细胞数量。正常动物的数值范围为466，000 - 643，000，但个体动物两侧之间的差异为9%或更少。在视神经再生过程中，单侧颅外视神经挤压后，实验视网膜中的细胞数量与未手术的伙伴相比下降，大部分损失发生在56 - 84天之间;到200天，仅剩下一半的细胞补体。由于辣根过氧化物的逆行运输标记了正常神经节细胞层中87%的细胞，因此再生过程中的大部分损失必须来自神经节细胞群。
Cell number in the retinal ganglion cell layer of adult Rana pipiens was estimated from cresyl stained wholemounts. Values for normal animals ranged from 466,000 to 643,000 but differences between sides of individual animals varied by 9% or less. During optic nerve regeneration, following unilateral extracranial optic nerve crush, cell numbers in experimental retinae fell compared to their unoperated partners with the majority of the loss taking place between 56 and 84 days; by 200 days only half the cell complement remained. Since retrograde transport of horseradish peroxide labelled 87% of cells in the normal ganglion cell layer, most of the loss during regeneration must have been from the ganglion cell population.