A versatile new preparation of cyclopropylamines from acid dialkylamides
A versatile new preparation of cyclopropylamines from acid dialkylamides
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DOI：
10.1002/anie.199604131
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发表时间：
1996-03-01
期刊：
影响因子：
--
通讯作者：
deMeijere, A
中科院分区：
文献类型：
--
作者：
Chaplinski, V;deMeijere, A
酸N，N-二烷基酰胺与烷基溴化镁在化学计量的四（2-丙醇）钛存在下的反应以中等至良好的产率产生二烷基环丙胺如1和2。以前难以获得的氨基环丙烷衍生物现在很容易获得。
The reaction of acid N, N‐dialkylamides with alkylmagnesium bromides in the presence of a stoichiometric amount of titanium tetra (2‐propanolate) produces dialkylcyclopropylamines like 1 and 2 in moderate to good yields. Previously inaccessible aminocyclopropane derivatives are now readily available.