Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
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DOI：
10.1194/jlr.r800085-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Abumrad, Nada A.
中科院分区：
文献类型：
--
作者：
Goldberg, Ira J.;Eckel, Robert H.;Abumrad, Nada A.
细胞从LPL催化的脂蛋白甘油三酯水解或从与白蛋白相关的未酯化的游离脂肪酸中获得脂肪酸。LPL还影响在血浆中不水解的酯化脂质如胆固醇酯和视黄酯的摄取。该过程可能不涉及LPL酶活性。LPL通过进食/禁食、胰岛素和运动调节。尽管许多分子可能影响FFA的细胞摄取，但最好的特征是CD 36。这种多配体受体的基因缺失减少了骨骼肌、心脏和脂肪组织对FFA的摄取，并损害了肠道乳糜微粒的产生和血液中脂蛋白的清除。jlr CD 36受一些调节LPL的相同因素的调节，包括胰岛素、肌肉收缩和禁食，部分通过泛素化。LPL和CD 36在各种组织中的作用协调脂肪来源的卡路里的生物分布。戈德堡岛J.，R. H.埃克尔和N. A.亚本拉德脂肪酸摄入组织的调节：脂蛋白脂酶和CD 36介导的途径。J. Lipid Res. 2009. S86-S90。
Cells obtain FAs either from LPL-catalyzed hydrolysis of lipoprotein triglyceride or from unesterified FFAs associated with albumin. LPL also influences uptake of esterified lipids such as cholesteryl and retinyl esters that are not hydrolyzed in the plasma. This process might not involve LPL enzymatic activity. LPL is regulated by feeding/fasting, insulin, and exercise. Although a number of molecules may affect cellular uptake of FFAs, the best characterized is CD36. Genetic deletion of this multiligand receptor reduces FFA uptake into skeletal muscle, heart, and adipose tissue, and impairs intestinal chylomicron production and clearance of lipoproteins from the blood.jlr CD36 is regulated by some of the same factors that regulate LPL, including insulin, muscle contraction, and fasting, in part, via ubiquitination. LPL and CD36 actions in various tissues coordinate biodistribution of fat-derived calories.-Goldberg, I. J., R. H. Eckel, and N. A. Abumrad. Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways. J. Lipid Res. 2009. S86-S90.