Enhancement of information transmission efficiency by synaptic failures
Enhancement of information transmission efficiency by synaptic failures
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DOI：
10.1162/089976604773717568
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发表时间：
2004-06-01
影响因子：
2.9
通讯作者：
Goldman, MS
中科院分区：
文献类型：
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作者：
Goldman, MS
许多突触有很高比例的突触传递失败。我认为，突触故障的假设，可以增加信息传输的效率通过突触。我使用每个囊泡释放的突触前锋电位序列作为突触传递效率的衡量标准，并表明，这一措施可以增加突触失败的概率。我分析计算香农互信息传输两个模型突触概率传输：一个与囊泡释放的恒定概率和囊泡释放概率由突触抑制的动态。对于由具有正自相关的非泊松过程产生的输入，两个突触都可以比具有完美传输的突触在每个囊泡释放中传输更多的信息，尽管对于具有相同平均传输概率的恒定概率突触，压抑突触的信息增加更大。抑制突触相对于恒定释放概率突触的增强的性能主要反映了噪声熵的降低而不是总传输熵的增加。这表明分析方法的局限性，如去相关，只考虑总的响应熵。我的研究结果表明，适当调整突触动力学控制的突触传递失败可以增加突触的信息携带效率。
Many synapses have a high percentage of synaptic transmission failures. I consider the hypothesis that synaptic failures can increase the efficiency of information transmission across the synapse. I use the information transmitted per vesicle release about the presynaptic spike train as a measure of synaptic transmission efficiency and show that this measure can increase with the synaptic failure probability. I analytically calculate the Shannon mutual information transmitted across two model synapses with probabilistic transmission: one with a constant probability of vesicle release and one with vesicle release probabilities governed by the dynamics of synaptic depression. For inputs generated by a non-Poisson process with positive autocorrelations, both synapses can transmit more information per vesicle release than a synapse with perfect transmission, although the information increases are greater for the depressing synapse than for a constant-probability synapse with the same average transmission probability. The enhanced performance of the depressing synapse over the constant-release-probability synapse primarily reflects a decrease in noise entropy rather than an increase in the total transmission entropy. This indicates a limitation of analysis methods, such as decorrelation, that consider only the total response entropy. My results suggest that synaptic transmission failures governed by appropriately tuned synaptic dynamics can increase the information-carrying efficiency of a synapse.