Comparative Anatomy of the Trabecular Meshwork, the Optic Nerve Head and the Inner Retina in Rodent and Primate Models Used for Glaucoma Research.
Comparative Anatomy of the Trabecular Meshwork, the Optic Nerve Head and the Inner Retina in Rodent and Primate Models Used for Glaucoma Research.
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DOI：
10.3390/vision1010004
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发表时间：
2016-07-18
期刊：
影响因子：
--
通讯作者：
Zhang, Hong
中科院分区：
文献类型：
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作者：
Chen, Liwen;Zhao, Yin;Zhang, Hong
青光眼是一组异质性的眼部疾病，具有多方面的病因。尽管已经发表了许多使用不同动物模型的青光眼研究，但由于动物眼睛的解剖和形态与人类相比存在差异，因此简单地将一种模型的结果推广到所有青光眼情况是不明智的。本文就小鼠、大鼠和猴的小梁网（TM）组织、筛板（LC）区、视神经乳头（ONH）和视网膜内层的差异作一综述。与人类相比，非人灵长类动物显示出在解剖学上几乎相同的TM、视网膜和ONH。与人类相比，大鼠模型在房水流出途径中显示出许多相似之处。小鼠ONH缺乏胶原LC，并且在不同小鼠品系中观察到该发现。啮齿类动物ONH的组织结构与人类相似，尽管血液供应显示差异。神经节层中的细胞数量取决于啮齿动物品系。尽管与人类存在一些差异，但啮齿类动物是研究不同类型青光眼的良好选择，建模方法应根据实验需要和所验证的假设进行选择。
Glaucoma is a heterogeneous group of ocular disorders with a multi-faceted etiology. Although numerous studies on glaucoma using different animal models have been published, it is unwise to simply generalize the results of one model to all glaucomatous situations because of the differences in the anatomy and morphology of animal eyes in comparison with humans'. In this review, we highlight the differences in the trabecular meshwork (TM) tissue, lamina cribrosa (LC) region, optic nerve head (ONH) and the inner layer of the retina in mice, rats and monkeys. In comparison with humans, non-human primates show TM, retina and ONH that are anatomically almost identical. The rat model shows many similarities in the aqueous outflow pathway compared to humans. The mouse ONH lacks collagenous LC, and this finding is observed across different mouse strains. The tissue structure of the ONH in rodents is similar to that in humans, although the blood supply shows differences. The number of cells in the ganglion layer depends on the rodent strain. Despite some differences from humans, rodents are a good choice for studying different types of glaucoma, and the modeling method should be selected based on the experimental needs and the hypothesis being tested.