Summary of Scientific and Statistical Methods, Study Endpoints and Definitions for Observational and Registry-Based Studies in Hematopoietic Cell Transplantation.
Summary of Scientific and Statistical Methods, Study Endpoints and Definitions for Observational and Registry-Based Studies in Hematopoietic Cell Transplantation.
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DOI：
10.2991/chi.d.191207.001
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发表时间：
2020-03
影响因子：
--
通讯作者：
Savani B
中科院分区：
文献类型：
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作者：
Kanate AS;Nagler A;Savani B
由于大多数科学出版物对单词/字符的限制越来越严格，我们确定需要一份主文件，说明可能适用于大多数造血细胞移植（HCT）观察性和基于注册的研究的“科学方法”。本研究旨在作为参考文件，描述HCT回顾性研究中最常用的数据来源、研究终点和统计分析。为此，我们编译，定义和参考HCT研究中常用的方法。虽然人们认识到，由于移植研究的不断发展，科学方法可能需要定期更新，例如更新的研究终点和统计方法，但本手稿描述了常用的方法。
Due to the increasingly strict word/character restrictions enforced by most scientific publications, we identified a need for a master document illustrating the “Scientific Methods” that may be applicable to the majority of observational and registry-based studies in hematopoietic cell transplantation (HCT). The purpose of this study is to serve as a reference document that describes the data source, study endpoints and statistical analyses utilized most commonly in retrospective studies in HCT. To this end we compile, define and reference the methodology commonly used in HCT research. While it is recognized that the scientific methodology may periodically require updates due to the evolving landscape of transplant research, such as newer study endpoints and statistical methods, this manuscript describes frequently used methodologies.