INCREASED PLASMA-FREE-FATTY-ACID CONCENTRATIONS AND THEIR SIGNIFICANCE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
INCREASED PLASMA-FREE-FATTY-ACID CONCENTRATIONS AND THEIR SIGNIFICANCE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
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DOI：
10.1016/s0140-6736(69)90749-1
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发表时间：
1969-01-01
期刊：
影响因子：
168.9
通讯作者：
OPIE, LH
中科院分区：
文献类型：
--
作者：
GUPTA, DK;JEWITT, DE;OPIE, LH
血浆（游离脂肪酸）对35例连续急性心肌梗死患者的游离脂肪酸浓度和尿儿茶酚胺排泄率进行了评估。高初始等离子体-F.F.A.值（>1000 μ mol/L）与严重心律失常的发生率增加有关。尿中游离肾上腺素的排泄与空腹血浆-F.F.A.程度.相比之下，空腹血浆-F.F.A.值与尿中游离去甲肾上腺素排泄量和空腹血清生长激素浓度均无关。本研究尚未确定高FFA的直接作用。在梗死后心律失常的产生中的价值。然而，静脉注射葡萄糖可降低血浆-F.F.A.水平有效。因此，应该有可能评估高FFA的作用。通过一项对照临床试验，在急性心肌梗死患者中使用静脉注射葡萄糖产生心律失常。
Plasma (F.F.A.) free-fatty-acid concentrations and urinary catecholamine-excretion rates were estimated in thirty-five consecutive patients with acute myocardial infarction. High initial plasma-F.F.A. values (>1000 μmole per litre) were associated with an increased incidence of serious cardiac arrhythmias. The excretion of free adrenaline in the urine correlated with the fasting plasma-F.F.A. levels. In contrast, fasting plasma-F.F.A. values were not related to either the urinary excretion of free noradrenaline nor to the fasting serum-growth-hormone concentration. This study has not established a direct role for high F.F.A. values in the production of cardiac arrhythmias after infarction. However, intravenous glucose reduced the elevated plasma-F.F.A. levels effectively. It should, therefore, be possible to evaluate the role of high F.F.A. values in the production of cardiac arrhythmias by a controlled clinical trial, using intravenous glucose in patients with acute myocardial infarction.