Williams syndrome hypersociability: A neuropsychological study of the amygdala and prefrontal cortex hypotheses
Williams syndrome hypersociability: A neuropsychological study of the amygdala and prefrontal cortex hypotheses
复制标题
DOI：
10.1016/j.ridd.2011.01.006
复制
发表时间：
2011-05-01
影响因子：
3.1
通讯作者：
Goncalves, Oscar F.
中科院分区：
文献类型：
--
作者：
Capitao, Liliana;Sampaio, Adriana;Goncalves, Oscar F.
患有威廉姆斯综合征的人对陌生人表现出不加选择的态度。迄今为止进行的神经影像学研究已将这种社会特征与WS杏仁核和前额叶皮质的结构和/或功能异常联系起来。在这项研究中，使用三项行为任务--面部情绪识别任务、社交接近任务和去不/去任务，探讨了杏仁核和前额叶皮质参与WS过度社交的神经心理学假设。因此，将一组15名患有威廉姆斯综合征的个体与两组正常发育的个体进行比较-一组15名在实足年龄（CA）上匹配的个体和15名在心理年龄（MA）和性别上匹配的个体。WS患者在识别负面面部表情方面存在特定障碍，与典型的发展中群体相比，在反应抑制方面没有表现出障碍。虽然这些研究结果部分支持杏仁核的贡献WS过度社交，我们发现，一般认知功能预测这种性能。此外，患有WS的个体在识别愤怒的面部表情方面与CA和MA组没有差异，这一发现表明他们实际上能够识别与社会威胁相关的刺激。总的来说，结果似乎表明，这种社会概况必须在发展框架内理解。(C)2011爱思唯尔有限公司保留所有权利。
Individuals with Williams syndrome display indiscriminate approach towards strangers. Neuroimaging studies conducted so far have linked this social profile to structural and/or functional abnormalities in WS amygdala and prefrontal cortex. In this study, the neuropsychological hypotheses of amygdala and prefrontal cortex involvement in WS hypersociability was explored using three behavioral tasks - facial emotional recognition task, a social approach task and a go no/go task. Thus, a group 15 individuals with Williams syndrome was compared to two groups of normal developing individuals - a group of 15 individuals matched for chronological age (CA) and 15 individuals matched for mental age (MA), and sex. Individuals with WS present a specific impairment in recognizing negative facial expressions and do not display impairments in response inhibition when compared with typically developing groups. Although these findings partially support the amygdala contribution to WS hypersociability, we found that general cognitive functioning predicted this performance. Additionally, individuals with WS did not differ from both CA and MA groups in the recognition of angry facial expressions, a finding suggesting that they are actually able to identify stimuli associated with social threat. Overall, the results seem to indicate that this social profile must be understood within a developmental framework. (C) 2011 Elsevier Ltd. All rights reserved.