DEXTROMETHORPHAN SUPPRESSES BOTH FORMALIN-INDUCED NOCICEPTIVE BEHAVIOR AND THE FORMALIN-INDUCED INCREASE IN SPINAL-CORD C-FOS MESSENGER-RNA
DEXTROMETHORPHAN SUPPRESSES BOTH FORMALIN-INDUCED NOCICEPTIVE BEHAVIOR AND THE FORMALIN-INDUCED INCREASE IN SPINAL-CORD C-FOS MESSENGER-RNA
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DOI：
10.1016/0304-3959(94)00214-y
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发表时间：
1995-06-01
期刊：
影响因子：
7.4
通讯作者：
INTURRISI, CE
中科院分区：
文献类型：
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作者：
ELLIOTT, KJ;BRODSKY, M;INTURRISI, CE
注射稀释福尔马林会导致刻板的伤害性行为反应。在足底内注射福尔马林前 30 分钟，皮下注射右美沙芬（皮下注射）而非生理盐水，可以剂量依赖性方式预防这种伤害性反应。此外，注射后 30 分钟通过定量溶液杂交进行评估，足底内福尔马林可靠地诱导同侧脊髓背角中的 c-fos mRNA。在对侧脊髓背角、中缝大核、导水管周围灰质、内侧丘脑或感觉运动皮层中未检测到 c-fos mRNA 变化。在福尔马林治疗前 30 分钟，皮下注射 60 mg/kg 右美沙芬进行预处理，导致 c-fos 诱导受到抑制，因此在福尔马林治疗前接受右美沙芬治疗的动物同侧脊髓背角中的 c-fos mRNA 水平与对照组没有差异。这些数据表明右美沙芬抑制福尔马林伤害感受行为和福尔马林伤害感受的生化后果之一，即诱导c-fos mRNA。
The injection of dilute formalin results in a stereotyped nociceptive behavioral response. Administration of dextromethorphan (s.c.) but not saline, 30 min prior to intraplantar formalin injection prevents this nociceptive response in a dose-dependent manner. In addition, intraplantar formalin reliably induces c-fos mRNA in the ipsilateral spinal dorsal horn as assessed with quantitative solution hybridization at 30 min postinjection. No change in c-fos mRNA was detected in the contralateral spinal dorsal horn, nucleus raphe magnus, periaqueductal grey, medial thalamus, or sensorimotor cortex. Pretreatment with dextromethorphan at 60 mg/kg s.c., 30 min prior to formalin resulted in a suppression of c-fos induction, so that c-fos mRNA levels in the ipsilateral spinal dorsal horn of animals receiving dextromethorphan prior to formalin did not differ from controls. These data indicate that dextromethorphan suppresses formalin nociceptive behavior and one of the biochemical consequences of formalin nociception, i.e., induction of c-fos mRNA.