Use of Hyaluronidase in the Treatment of Granulomatous Hyaluronic Acid Reactions or Unwanted Hyaluronic Acid Misplacement
Use of Hyaluronidase in the Treatment of Granulomatous Hyaluronic Acid Reactions or Unwanted Hyaluronic Acid Misplacement
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DOI：
10.1111/j.1524-4725.2005.31801
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发表时间：
2005-08
影响因子：
2.4
通讯作者：
H. Brody
中科院分区：
文献类型：
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作者：
H. Brody
背景在过去，软组织填充物的反应或错位一直充满焦虑，因为时间一直是改善的主要推动力，尽管有辅助治疗。透明质酸酶是一种溶解皮肤中透明质酸的酶，也有助于管理对透明质酸的肉芽肿性异物反应。这些反应可能是由对材料的过敏或对透明质酸制剂中蛋白质污染物的免疫反应引起的。材料在错误放置和过敏反应中的溶解可以节省时间并防止患者不满。目的探讨透明质酸酶在治疗皮肤过敏反应和透明质酸误置中的应用。方法报告1例注射透明质酸引起的持续性肉芽肿反应和1例透明质酸误放，经皮内注射透明质酸酶治疗后均获成功，并附沿着透明质酸酶治疗的实例。结果透明质酸酶的使用在24至48小时内减轻了患者的不适，阻止了患者的焦虑或不满。结论透明质酸酶在治疗透明质酸酶过敏反应和材料错误放置中具有一定的应用价值。
Background In the past, reactions or misplacement of soft tissue fillers has been fraught with anxiety because time has been the main thrust for improvement in spite of ancillary treatments. Hyaluronidase is an enzyme that dissolves hyaluronic acid in the skin and also assists in the management of granulomatous foreign-body reactions to hyaluronic acid. These reactions may be caused by allergy to the material or immunologic response to the protein contaminants in the hyaluronic acid preparations. Dissolution of material in erroneous placement of material and in allergic reactions can be a time saver and a deterrent to patient dissatisfaction. Objective To evaluate the use of hyaluronidase in the treatment of both allergic reactions and the erroneous misplacement of hyaluronic acid in the skin. Methods A case of persistent granulomatous reaction to injectable hyaluronic acid and a case of hyaluronic acid erroneous misplacement with their successful subsequent treatments using intracutaneous hyaluronidase are reported, along with illustrative examples of hyaluronidase use. Results The use of hyaluronidase reduced the patient discomfort within 24 to 48 hours, deterring any patient anxiety or patient dissatisfaction. Conclusions Hyaluronidase has a place in the treatment of allergic reactions to hyaluronidase and in the erroneous misplacement of the material.