Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
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DOI：
10.1126/science.1132894
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发表时间：
2007-01-12
期刊：
影响因子：
56.9
通讯作者：
Johnson, Patricia J.
中科院分区：
文献类型：
--
作者：
Carlton, Jane M.;Hirt, Robert P.;Johnson, Patricia J.
我们描述了原生生物阴道毛滴虫的基因组序列，它是一种性传播的人类病原体。重复序列和转座元件约占这个约1.6亿碱基对基因组的三分之二，反映了近期遗传物质的大量扩增。这种扩增，连同可能通过从细菌横向基因转移而发生的代谢途径的形成，以及与发病机制和宿主蛋白质吞噬作用有关的特定基因家族的扩增，可能体现了该寄生虫在向泌尿生殖道环境过渡期间的适应性变化。基因组序列预测了氢化酶体以前未知的功能，这支持了这种不寻常的细胞器与线粒体有共同的进化起源。
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the similar to 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.