Transcranial direct current stimulation does neither modulate results of a quantitative sensory testing protocol nor ratings of suprathreshold heat stimuli in healthy volunteers
Transcranial direct current stimulation does neither modulate results of a quantitative sensory testing protocol nor ratings of suprathreshold heat stimuli in healthy volunteers
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DOI：
10.1002/j.1532-2149.2012.00135.x
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发表时间：
2012-10-01
影响因子：
3.6
通讯作者：
May, A.
中科院分区：
文献类型：
--
作者：
Juergens, T. P.;Schulte, A.;May, A.
经颅直流电刺激（tDCS）已被证明可以有效地调节皮质兴奋性。几项研究表明，在疼痛综合征，如中枢神经性疼痛或纤维肌痛的临床疗效。然而，关于tDCS对健康志愿者伤害感受的影响知之甚少。方法在本研究中，我们研究了17名健康志愿者的左初级运动皮层的阳极，阴极和假刺激对全面的定量感觉测试协议（包括热和机械感受性检测和疼痛阈值）的模式和模仿临床疼痛的重复热痛范例的影响。本研究以单盲交叉方式进行。tDCS应用于1？mA为15？结果在定量感觉测试中，我们不能检测到任何相关的躯体感觉和疼痛变量的调制。结论慢性疼痛患者的疼痛过程可能存在差异，tDCS的抗伤害性效应取决于伤害性系统的激活水平。
Background Transcranial direct current stimulation (tDCS) has been shown to effectively modulate cortical excitability. Several studies have suggested clinical efficacy in pain syndromes such as central neuropathic pain or fibromyalgia. However, little is known regarding tDCS effects on nociception in healthy volunteers. Methods In the present study, we examined the effects of anodal, cathodal and sham stimulation of the left primary motor cortex in 17 healthy volunteers on modalities of a comprehensive quantitative sensory testing protocol (including thermal and mechanoreceptive detection and pain thresholds) and on a repetitive heat pain paradigm mimicking clinical pain. The study was conducted in a single-blind crossover fashion. tDCS was applied at 1?mA for 15?min. Results We could not detect any relevant modulation of somatosensory and pain variables in quantitative sensory testing. In addition, no significant alteration of enhanced pain ratings to repetitive noxious heat stimuli (heat hyperalgesia) was found. Conclusion As pain processing in chronic pain patients might differ, tDCS could exert its antinociceptive effects depending on the activation level of the nociceptive system.