Gastric cancer: Basic aspects
Gastric cancer: Basic aspects
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DOI：
10.1111/hel.12412
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发表时间：
2017-09-01
期刊：
影响因子：
4.4
通讯作者：
Varon, Christine
中科院分区：
文献类型：
--
作者：
Molina-Castro, Silvia;Pereira-Marques, Joana;Varon, Christine
胃癌是世界上发病率最高、死亡率最高的恶性肿瘤之一。胃癌是一种异质性疾病，是一个漫长的多步骤过程的终点，这是由于许多（epi）遗传改变的逐步积累，导致致癌和抑癌途径的失调。胃癌干细胞已成为癌症发展的基本参与者，并成为胃癌异质性的贡献者。在这期特刊中，我们将报告去年胃癌分子分类的最新情况，特别是可以从免疫检查点治疗中受益的胃癌组。我们还将综述胃癌干细胞的最新研究进展，其作为胃癌标志物和治疗靶点的特性，以及相关的信号通路。了解胃癌异质性的分子基础以及胃癌干细胞在癌症发展和异质性中所起的作用，不仅对于确定癌症预防和治疗的新靶点，而且对于临床管理和靶向治疗的患者分层具有重要意义。
Gastric cancer is one of the most incident and deadliest malignancies in the world. Gastric cancer is a heterogeneous disease and the end point of a long and multistep process, which results from the stepwise accumulation of numerous (epi) genetic alterations, leading to dysregulation of oncogenic and tumor suppressor pathways. Gastric cancer stem cells have emerged as fundamental players in cancer development and as contributors to gastric cancer heterogeneity. For this special issue, we will report last year's update on the gastric cancer molecular classification, and in particular address the gastric cancer groups who could benefit from immune checkpoint therapy. We will also review the latest advances on gastric cancer stem cells, their properties as gastric cancer markers and therapeutic targets, and associated signaling pathways. The understanding of the molecular basis underlying gastric cancer heterogeneity and of the role played by gastric cancer stem cells in cancer development and heterogeneity is of major significance, not only for identifying novel targets for cancer prevention and treatment, but also for clinical management and patient stratification for targeted therapies.