Lupus nephritis in children
Lupus nephritis in children
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DOI：
10.1191/0961203305lu2065oa
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Martini, A
中科院分区：
文献类型：
--
作者：
Perfumo, F;Martini, A
在系统性红斑狼疮中，肾脏受累在儿童比成人更常见。总体而言，60-80%的系统性红斑狼疮患儿在病程早期有泌尿或肾功能异常。在90%的患者中，肾脏疾病发生在疾病发作的两年内。临床上显著的肾脏受累范围从无症状的泌尿系统发现到肾病综合征和肾衰竭。长期预后与成人相似。儿童特有的治疗方面包括药物副作用，如类固醇引起的生长抑制，需要考虑与病人预期寿命很长有关的发病率问题，以及与疾病对青少年的影响有关的问题。最近可用的儿童SLE改善的定义和存在的大型国际儿科风湿病网络，在未来，促进实施对照临床试验致力于儿科SLE。
In systemic lupus erythematosus renal involvement is more frequent in children than in adults. Overall, 60-80% of children with systemic lupus erythematosus have urinary or renal function abnormalities early in the disease course. In 90% of patients, renal disease occurs within two years from disease onset. Clinically significant renal involvement ranges from asymptomatic urinary findings to nephrotic syndrome and renal failure. Long-term prognosis is similar to that observed in adults. Treatment aspects that are peculiar to children include drug side-effects, such as growth inhibition induced by steroids, the need to consider morbidity-related issues with respect to the very long life expectancy of patients and the problems related to the impact of disease in adolescents. The recent availability of a childhood SLE definition of improvement and the presence of large international paediatric rheumatology networks should, in the future, facilitate the implementation of controlled clinical trials devoted to paediatric SLE.