Lactate dehydrogenase, Catalase, and Superoxide dismutase in Tumor Tissue of Breast Cancer Patients in Respect to Mammographic Findings
Lactate dehydrogenase, Catalase, and Superoxide dismutase in Tumor Tissue of Breast Cancer Patients in Respect to Mammographic Findings
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DOI：
10.1007/s12013-012-9482-7
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Jurisic, Vladimir
中科院分区：
文献类型：
--
作者：
Radenkovic, Sandra;Milosevic, Zorica;Jurisic, Vladimir
乳酸脱氢酶（LDH）是无氧代谢的标志物，与高度浸润和转移的乳腺癌相关。新的研究表明，无氧代谢（LDH）增加，以及抗氧化酶（超氧化物歧化酶（SOD）和过氧化氢酶（CAT））的活性，与较高的乳腺摄影密度相关，作为乳腺癌风险的已知预测因素。本研究采用分光光度法测定了乳腺癌患者癌组织及癌旁组织中LDH、MDH和SOD的活性。根据美国放射学会乳腺成像报告和数据系统对乳房X线照片进行评价。乳腺癌患者的乳腺组织中，乳腺摄影致密的乳腺组织与较高的LDH活性相关。此外，与病灶不对称或结构扭曲的患者相比，肿块患者的LDH活性显著更高。与病灶不对称或结构扭曲的患者相比，毛刺状肿块边缘的患者LDH活性更高。随着BIRADS分级的增加，患者LDH活性显著升高，CAT活性显著降低。这些结果提示肿瘤组织中LDH和CAT的活性与乳腺X线摄影特征的关联可能有助于定义侵袭性乳腺癌。
Lactate dehydrogenase (LDH), marker of anaerobic metabolism, is associated with highly invasive and metastatic breast cancer. Novel studies show that increased anaerobic metabolism (LDH), as well as activity of antioxidative enzymes (superoxide dismutase (SOD) and catalase (CAT)), is correlated with higher mammographic density, as known predictor of breast cancer risk. In this study, we measured LDH, MDH, and SOD activity in tumor and adjacent tissues of breast cancer patients by spectrophotometric assay. Mammograms were evaluated according to the American College of Radiology Breast Imaging Reporting and Data system. Mammographically dense breast tissue is associated with higher activity of LDH in tumor tissue of breast cancer patients. Moreover, patients with masses have significantly higher activity of LDH compared to patients with focal asymmetries or architectural distortion. Patients with spiculated mass margin had higher activity of LDH compared to patients with focal asymmetries or architectural distortion. Activity of LDH in patients significantly increases, while activity of CAT significantly decreases with the increase of BIRADS category. These results suggest that the association of activity of LDH and CAT in tumor tissue with mammographic characteristics could help in defining aggressive breast cancers.