Pharmacokinetics : Processes, Mathematics, and Applications
Pharmacokinetics : Processes, Mathematics, and Applications
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药代动力学：过程、数学和应用
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
P. Welling
中科院分区：
文献类型：
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作者：
P. Welling
药代动力学是研究药物在人体中的吸收、分布、代谢和排泄的学科。本书由国际知名研究人员撰写，讲授药物的基本原理，包括药物转运、肠外和肠内给药途径以及影响药物吸收、分布和代谢的因素。该版本经过广泛修订，介绍了各种单室和多室模型的药代动力学数学，包括代谢物和非线性药代动力学的详细描述。它还描述了肾脏和肝脏药物清除率，以及肾脏和肝脏损伤对这些功能的影响。作者自始至终采用教程方法，对药代动力学进行了清晰的介绍，并对这门科学如何影响药物发现和开发进行了批判性的审视。
Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.