Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.
Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.
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DOI：
10.1038/srep22251
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发表时间：
2016-02-25
影响因子：
4.6
通讯作者：
Nakajima A
中科院分区：
文献类型：
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作者：
Kessoku T;Imajo K;Honda Y;Kato T;Ogawa Y;Tomeno W;Kato S;Mawatari H;Fujita K;Yoneda M;Nagashima Y;Saito S;Wada K;Nakajima A
天然多酚化合物白藜芦醇（RSV）被认为对人类健康具有广泛的有益生物活性。然而，RSV 对脂肪变性（非酒精性脂肪肝 [NAFL] 的一种表型）或纤维化和炎症（非酒精性脂肪性肝炎 [NASH] 的主要表型）的确切影响尚不清楚。我们的数据表明，在高脂饮食诱导的小鼠 NAFL 模型中，施用 RSV（2 或 20mg/kg/天）并不能抑制脂肪变性。相比之下，在低剂量脂多糖诱导的 NASH 模型中，相同浓度的 RSV 可显着抑制炎症和纤维化。这些数据表明，RSV 给药介导的炎症和纤维化改善是由于库普弗细胞中 CD14 表达控制的 LPS 反应性受到抑制。这些发现表明 RSV 可能是治疗 NASH 的候选药物。
The natural polyphenol compound resveratrol (RSV) is considered to have a broad spectrum of beneficial biological activities upon human health. However, the exact effect of RSV on steatosis (a phenotype of non-alcoholic fatty liver [NAFL]) or fibrosis and inflammation (major phenotypes of non-alcoholic steatohepatitis [NASH]) is not known. Our data showed that administration of RSV (2 or 20 mg/kg/day) did not suppress steatosis in a high-fat diet-induced model of NAFL in mice. In contrast, identical concentrations of RSV dramatically inhibited inflammation and fibrosis in a low-dose lipopolysaccharide-induced model of NASH. These data suggested that RSV administration-mediated improvement of inflammation and fibrosis was due to the inhibition of LPS reactivity controlled by CD14 expression in Kupffer cells. These findings suggest that RSV could be a candidate agent for the treatment of NASH.