An in vitro study of boronated porphyrins for potential use in boron neutron capture therapy
An in vitro study of boronated porphyrins for potential use in boron neutron capture therapy
复制标题
硼化卟啉在硼中子捕获疗法中的潜在用途的体外研究
DOI：
10.1016/s0960-894x(01)81006-4
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发表时间：
1993
影响因子：
2.7
通讯作者：
A. Morgan
中科院分区：
文献类型：
--
作者：
K. Woodburn;A. Phadke;A. Morgan
研究了一系列亲脂性和双醚侧链长度不同的硼化血卟啉类似物及其锌衍生物在硼中子俘获治疗中的应用。在300 μM的浓度下，卟啉对V79细胞没有固有的细胞毒性。细胞摄取随亲脂性和金属化而变化。
A series of boronated hematoporphyrin analogs differing in lipophilicity and in the length of the di-ether side chains, and their zinc derivatives were evaluated for use in boron neutron capture therapy. The porphyrins displayed no inherent cytotoxicity towards V79 cells at a concentration of 300 μM. Cellular uptake varied as a function of lipophilicity and metallation.