High-density lipoprotein cholesterol and objective measures of lower extremity performance in older nondisabled persons: the InChianti study.
High-density lipoprotein cholesterol and objective measures of lower extremity performance in older nondisabled persons: the InChianti study.
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高密度脂蛋白胆固醇和老年非残疾人下肢性能的客观测量：InChianti 研究。
DOI：
10.1111/j.1532-5415.2007.01608.x
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发表时间：
2008
影响因子：
6.3
通讯作者：
Guralnik,JackM
中科院分区：
文献类型：
--
作者：
Volpato,Stefano;Ble,Alessandro;Metter,EJeffrey;Lauretani,Fulvio;Bandinelli,Stefania;Zuliani,Giovanni;Fellin,Renato;Ferrucci,Luigi;Guralnik,JackM
目的：评估高密度脂蛋白胆固醇 (HDL-C) 水平与下肢表现客观测量之间的独立关联。设计：横断面队列研究。设置：以社区为基础。参与者：参加 Invecchiare in Chianti 研究的 836 名 65 岁及以上的非残疾女性和男性。测量：下肢表现采用以下方法进行评估： 4 米快步步行速度、400 米步行速度和膝关节伸展扭矩。使用商业酶测试测定空腹 HDL-C 水平。结果：参与者的平均年龄为 73.7 岁（65-92 岁），其中 55.6% 为女性。调整潜在的混杂因素（社会人口因素、吸烟、体力活动、身体成分以及包括心脑血管疾病、炎症标志物和血清睾酮在内的临床状况）后，HDL-C 水平与男性和女性的膝关节伸展扭矩以及男性的 4 米和 400 米步行速度显着相关。 HDL-C 分布最高三分位数 (>55 mg/dL) 的男性平均而言，属于所有下肢性能指标最佳三分位数的概率高出三倍，包括 4 米快走速度（比值比 (OR)=2.57，95%=置信区间 (CI)=1.07–6.17）、400 米步行速度（OR=3.74，95% CI=1.20–11.7）和膝关节伸展扭矩（OR=3.63，95%=CI 1.41–9.33）。路径分析表明 HDL-C 与膝关节伸展扭矩之间存在直接关系。结论：在老年非残疾人中，HDL-C 水平与膝关节伸展扭矩和步行速度高度相关。进一步的研究应集中于这种关联的生物学机制。
OBJECTIVES:To evaluate the independent association between high‐density lipoprotein cholesterol (HDL‐C) levels and objective measures of lower extremity performance.DESIGN:Cross‐sectional cohort study.SETTING:Community‐based.PARTICIPANTS:Eight hundred thirty‐six nondisabled women and men aged 65 and older enrolled in the Invecchiare in Chianti study.MESASUREMENTS:Lower extremity performance was assessed using 4‐m walking speed at fast pace, 400‐m walking speed, and knee extension torque. Fasting HDL‐C levels were determined using commercial enzymatic tests.RESULTS:The mean age of participants was 73.7 (65–92), and 55.6% were women. After adjusting for potential confounders (sociodemographic factors, smoking, physical activity, body composition, and clinical conditions including cardiovascular and cerebrovascular disease, inflammatory markers, and serum testosterone) HDL‐C levels were significantly associated with knee extension torque in men and women and with 4‐m and 400‐m walking speed in men. Men in the highest tertile of the HDL‐C distribution (>55 mg/dL) had, on average, a three times greater probability of belonging to the best tertile of all indexes of lower extremity performance, including 4‐m fast walking speed (odds ratio (OR)=2.57, 95%=confidence interval (CI)=1.07–6.17), 400‐m walking speed (OR=3.74, 95% CI=1.20–11.7), and knee extension torque (OR=3.63, 95%=CI 1.41–9.33). Path analysis suggested a direct relationship between HDL‐C and knee extension torque.CONCLUSION:In older nondisabled persons, HDL‐C levels are highly correlated with knee extension torque and walking speed. Further research should focus on the biological mechanism of this association.