Development of macropores in calcium carbonate body using novel carbonation method of calcium hydroxide/sodium chloride composite
Development of macropores in calcium carbonate body using novel carbonation method of calcium hydroxide/sodium chloride composite
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DOI：
10.1007/s10853-006-0747-7
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发表时间：
2007-04
影响因子：
4.5
通讯作者：
Yoong Lee;Y. Hahm;S. Matsuya;M. Nakagawa;K. Ishikawa
中科院分区：
文献类型：
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作者：
Yoong Lee;Y. Hahm;S. Matsuya;M. Nakagawa;K. Ishikawa
碳酸钙是生物陶瓷的一种，在临床上已被用作牙科和骨科手术的骨替代物。强烈建议在生物陶瓷中引入大孔，因为这些孔可以促进组织向内生长并加速骨整合。本文尝试采用氢氧化钙/氯化钠复合碳化新方法制备具有大孔隙的碳酸钙体。氯化钠在碳酸钙体形成大孔隙中起水溶性成孔剂的作用，碳酸化后用蒸馏水洗涤可将其完全去除。研究了氯化钠含量和成型压力对碳酸钙体孔隙率和机械强度的影响。通过研究发现，随着复合材料中氯化钠含量的增加，复合材料体的孔隙率增加，并且受成型压力的影响很小。机械强度随成型压力的增大而增大，随孔隙率的增大而减小。此外，氯化钠含量的增加使孔尺寸增大，孔间的连通程度增强。特别是当90áwt时，可以制备孔隙率超过90%的碳酸钙体。在10áMPa成型压力下使用%氯化钠。其平均孔隙和孔径分别为177和80áμm。
Calcium carbonate is one of the bioceramics and has been used clinically as a bone substitute in dental and orthopedic surgery. Introduction of macropores into the bioceramics is highly recommended because those pores enable tissue ingrowth and accelerated osteointegration. We tried to prepare calcium carbonate body with macropores through the new carbonation method of calcium hydroxide/sodium chloride composite. Sodium chloride acted as a water-soluble porogen in developing macropores in calcium carbonate body and was removed completely by washing with distilled water after carbonation. We investigated effects of sodium chloride content and molding pressure on the porosity and the mechanical strength of the calcium carbonate body. Through this study, it was found that the porosity of body increased with the sodium chloride content in composite and was hardly affected by molding pressure. On the other hand, the mechanical strength was increased with the molding pressure and reduced with the porosity. In addition, the increase in content of sodium chloride caused the enlargement of hole size as well as the enhancement of extent of interconnection among pores through hole. Especially, the calcium carbonate body with over 90% porosity could be prepared when 90áwt.% sodium chloride was used under 10áMPa molding pressure. Its average pore and hole size were 177 and 80áμm, respectively.