Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.
Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.
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DOI：
10.1016/j.neuint.2011.09.007
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发表时间：
2012-06
影响因子：
4.2
通讯作者：
Norenberg MD
中科院分区：
文献类型：
--
作者：
Rama Rao KV;Norenberg MD
急性和慢性肝性脑病(HE)的一种机制是大脑能量代谢障碍。本文综述了这一机制在急性和慢性肝性脑病以及其他高氨血症疾病中的研究现状。本文综述了糖酵解、乳酸代谢、柠檬酸循环、氧化磷酸化及相关的能量损伤的异常。此外，强调了线粒体通透性转变(MPT)的作用，这是最近建立的一个因素，在HE和高氨血症的发病机制中。能量衰竭似乎是急性和慢性肝性脑病的重要致病因素，也是潜在的治疗靶点。
One proposed mechanism for acute and chronic hepatic encephalopathy (HE) is a disturbance in cerebral energy metabolism. This article reviews the current status of this mechanism in both acute and chronic HE, as well as in other hyperammonemic disorders. This article reviews abnormalities in glycolysis, lactate metabolism, citric acid cycle, and oxidative phosphorylation and associated energy impairment. Additionally, the role of mitochondrial permeability transition (mPT), a recently established factor in the pathogenesis of HE and hyperammonemia, is emphasized. Energy failure appears to be an important pathogenetic component of both acute and chronic HE and a potential target for therapy.