Molecular mechanisms involved in mesenchymal stem cell migration to the site of acute myocardial infarction.
Molecular mechanisms involved in mesenchymal stem cell migration to the site of acute myocardial infarction.
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DOI：
10.1155/2009/904682
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发表时间：
2009
影响因子：
--
通讯作者：
Brooke G
中科院分区：
文献类型：
--
作者：
Kollar K;Cook MM;Atkinson K;Brooke G
一些研究表明，间充质干细胞或多能间充质基质细胞（简称MSC）对梗死后心肌恢复有有益作用。目前骨髓间充质干细胞心脏输送的策略包括静脉、动脉和肌肉内输送。不同的骨髓间充质干细胞传递途径和缺乏对骨髓间充质干细胞在体内迁移机制的了解，很可能导致了已经发现的结果的显著差异。本综述旨在总结MSC迁移机制的现有知识，并展望未来在分娩前操纵MSC的方法，以增强MSC迁移和植入。
Mesenchymal stem cells or multipotent mesenchymal stromal cells (both referred to as MSC) have been shown in some studies to have a beneficial effect on myocardial recovery after infarct. Current strategies for MSC delivery to heart involve intravenous, intraarterial, and intramuscular delivery. Different routes of MSC delivery and a lack of knowledge of the mechanisms that MSC utilise to migrate in vivo has most likely led to the marked variations in results that have been found. This review aims to summarise the current knowledge of MSC migratory mechanisms and looks to future methods of MSC manipulation prior to delivery in order to enhance MSC migration and engraftment.