Interpretation of serologic tests for typhoid fever.
Interpretation of serologic tests for typhoid fever.
复制标题
伤寒血清学检测的解释。
DOI：
10.1001/jama.1968.03150040051012
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
S. Schroeder
中科院分区：
文献类型：
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作者：
S. Schroeder
尽管该国伤寒的发病率一直在下降，但1仍有零星爆发。2，3越来越多的军人和普通公民在前往伤寒流行地区的国外旅行中暴露于伤寒;因此，伤寒的诊断仍然是一个重要问题。确定的诊断方法是从血液、粪便或偶尔尿液中分离出伤寒沙门氏菌，但血清学试验仍被广泛使用。本文将简要讨论伤寒血清学试验的以下几个方面：使用的抗原，与其他沙门氏菌的交叉反应性，试验结果的传统解释标准，接种疫苗患者的血清学反应，抗生素治疗对抗体反应的影响，以及鉴定伤寒携带者的Vi试验。伤寒杆菌的诊断试验，如肥达氏反应，是试管稀释试验，测量抗O和H抗原的凝集抗体。使用Vi抗原
Although the incidence of typhoid fever in this country has been decreasing,1sporadic outbreaks continue to occur.2,3Increasing numbers of military personnel and private citizens are being exposed to typhoid during foreign travel to areas where the disease is endemic; consequently, the diagnosis of typhoid fever remains an important problem. The definitive diagnostic procedure is isolation ofSalmonella typhosafrom blood, stool, or occasionally, urine, but serologic tests are still widely used. This communication will briefly discuss the following aspects of serologic tests for typhoid fever: the antigens used, cross-reactivity with other salmonellae, traditional interpretive criteria of test results, serologic response in the vaccinated patient, the effect of antibiotic treatment on antibody response, and the Vi test for identifying typhoid carriers. Diagnostic tests for typhoid bacillus, such as Widal's reaction, are tube dilution tests which measure agglutinating antibodies against O and H antigens. The Vi antigen is used