Patients with inflammatory bowel disease have an increased risk of myocardial infarction: a nationwide study
Patients with inflammatory bowel disease have an increased risk of myocardial infarction: a nationwide study
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DOI：
10.1111/apt.15446
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发表时间：
2019-10-01
影响因子：
7.6
通讯作者：
Kim, Nayoung
中科院分区：
文献类型：
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作者：
Choi, Yoon Jin;Lee, Dong Ho;Kim, Nayoung
研究背景炎症性肠病（IBD）伴有全身性炎症和高凝状态等多种肠外表现，可增加动脉粥样硬化和缺血性心脏病的风险。目的探讨炎症性肠病（IBD）是否与心肌梗死（MI）、脑卒中或死亡的风险增加有关。方法采用国际疾病分类第10版编码和罕见病索赔编码，从韩国国家健康保险局（NHIS）中筛选候选人。2006年至2009年期间诊断为克罗恩病（CD）或溃疡性结肠炎（UC）的患者与无IBD的NHIS入组者年龄匹配1：3。主要结局包括新发MI、卒中和死亡。使用考克斯回归模型计算风险比（HR）和95%置信区间（CI）。结果共确诊CD患者10708例，UC患者26769例。CD患者的MI风险高于对照组（发病率比（IR）为1.64/1000人-年，HR为1.80; 95%CI为1.47-2.21），且这一趋势在年龄较大的患者中更为突出。
Background Inflammatory bowel disease (IBD) is accompanied by various extraintestinal manifestations including systemic inflammation and hypercoagulability, which may increase the risk of atherosclerosis and ischaemic heart disease. Aim To investigate whether IBD is associated with an increased risk of myocardial infarction (MI), stroke or death Methods The International Classification of Disease, 10th edition codes and the claim codes for rare diseases were used to identify candidates from National Health Insurance Service (NHIS) of South Korea. Patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between 2006 and 2009 were age-matched 1:3 with NHIS enrolees without IBD. The primary outcomes included newly developed MI, stroke and death. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results We identified 10 708 patients diagnosed with CD and 26 769 with UC. MI risk was higher in CD patients than in controls (incidence ratio (IR) 1.64 per 1000 person-years, HR, 1.80; 95% CI, 1.47-2.21), and this trend was more prominent among patients aged