Bone Mineral Density of Human Female Cervical and Lumbar Spines From Quantitative Computed Tomography
Bone Mineral Density of Human Female Cervical and Lumbar Spines From Quantitative Computed Tomography
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定量计算机断层扫描人类女性颈椎和腰椎的骨矿物质密度
DOI：
10.1097/01.brs.0000192684.12046.93
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发表时间：
2006
期刊：
影响因子：
3
通讯作者：
G. Paskoff
中科院分区：
文献类型：
--
作者：
N. Yoganandan;F. Pintar;B. Stemper;J. Baisden;R. Aktay;B. Shender;G. Paskoff
研究设计.本研究测定了健康无症状受试者颈椎、胸椎和腰椎的骨矿物质密度（BMD）。目标.验证颈椎（C2-C7）BMD与腰椎（L2-L4）BMD相当的假设。背景数据总结。腰椎骨密度与其强度相关。虽然存在许多研究量化人体腰椎的BMD，但颈椎的此类信息非常有限。此外，在脊柱的两个区域之间没有建立BMD相关性。方法.年龄范围为18至40岁的成年健康人类女性志愿者接受颈部和背部的定量计算机断层扫描（CT）扫描。所有BMD数据采用配对非重复测量ANOVA技术进行统计学分析。显著性指定为P < 0.05。线性回归分析用于比较BMD作为水平和区域的函数;确定±95%置信区间。结果当数据按颈椎（C2-C7）、胸椎（T1）和腰椎（L2-L4）进行分组时，平均BMD分别为260.8 ± 42.5、206.9 ± 33.5和179.7 ± 23.4 mg/mL。颈椎骨密度高于胸腰椎（P < 0.0001）。BMD和水平之间的相关性表明T1的r值最低（0.42）;一般而言，腰椎的相关性最强（r = 0.89-0.95）。颈椎也与颈椎之间的良好相关性（r范围为0.66至0.87）。结论.本研究未能支持腰椎骨密度与颅骨骨密度相当的假设。三个腰椎椎体之间的BMD无差异证实了在临床或生物力学情况下使用L2、L3或L4的适当性。然而，在脊柱的不同区域之间发现了显著差异，颈椎的骨小梁密度高于胸椎和腰椎。此外，本研究发现，即使在颈椎之间，密度也存在统计学显著差异。
Study Design. This study determined bone mineral density (BMD) of cervical, thoracic, and lumbar vertebrae in healthy asymptomatic human subjects. Objectives. To test the hypothesis that BMD of neck vertebrae (C2–C7) is equivalent to BMD of lumbar vertebrae (L2–L4). Summary of Background Data. BMD of lumbar vertebrae is correlated to their strength. Although numerous studies exist quantifying BMD of the human lumbar spine, such information for the cervical spine is extremely limited. In addition, BMD correlations are not established between the two regions of the spinal column. Methods. Adult healthy human female volunteers with ages ranging from 18 to 40 years underwent quantitative computed tomography (CT) scanning of the neck and back. All BMD data were statistically analyzed using paired nonrepeating measures ANOVA techniques. Significance was assigned at a P < 0.05. Linear regression analyses were used to compare BMD as a function of level and region; ±95% confidence intervals were determined. Results. When data were grouped by cervical (C2–C7), thoracic (T1), and lumbar (L2–L4) spines, mean BMD was 260.8 ± 42.5, 206.9 ± 33.5, and 179.7 ± 23.4 mg/mL. Average BMD of cervical vertebrae was higher than (P < 0.0001) thoracic and lumbar spines. Correlations between BMD and level indicated the lowest r value for T1 (0.42); in general, the association was the strongest in the lumbar spine (r = 0.89–0.95). The cervical spine also responded with good correlations among cervical vertebrae (r ranging from 0.66 to 0.87). Conclusions. The present study failed to support the hypothesis that BMD of lumbar spine vertebrae is equivalent to its cranial counterparts. The lack of differences in BMD among the three lumbar vertebral bodies confirms the appropriateness of using L2, L3, or L4 in clinical or biomechanical situations. However, significant differences were found among different regions of the vertebral column, with the cervical spine demonstrating higher trabecular densities than the thoracic and lumbar spines. In addition, the present study found statistically significant variations in densities even among neck vertebrae.
DOI：
10.1016/0141-5425(90)90127-9
发表时间：
1990
期刊：
Journal of biomedical engineering
影响因子：
--
作者：
Yoganandan,N;Pintar,F;Wilson,CR;SancesJr,A
通讯作者：
SancesJr,A