Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
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DOI：
10.1172/jci200320074
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发表时间：
2003-11-01
影响因子：
15.9
通讯作者：
Givskov, M
中科院分区：
文献类型：
--
作者：
Hentzer, M;Givskov, M
传染病的传统治疗是基于旨在杀死或抑制细菌生长的化合物。这种方法的一个主要问题是经常观察到的抗微生物化合物耐药性的发展。细菌通讯系统（群体感应系统）的发现，在感染过程中的重要时间事件的编排，提供了一个新的机会，以改善细菌感染的手段以外的生长抑制。能够覆盖细菌信号的化合物存在于自然界中。在这里，我们讨论了已知的信号传导机制和潜在的抗病药物，专门针对群体感应系统的方式不太可能构成耐药突变体的发展的选择压力。
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.